Gastrin and cholecystokinin in pituitary neurons.
Authors:
- J F RehfeldJRJ F Rehfeld
- H F HansenHHH F Hansen
- L I LarssonLLL I Larsson
- K Stengaard-PedersenKSK Stengaard-Pedersen
- N A ThornNTN A Thorn
Open Access
- 1 March 1984
- journal article
- research article
- Published by National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 81 (6) , 1902-1905
Abstract
Gastrins occur in the hypothalamo-hypophyseal neurons of all mammalian species examined. In addition, human, bovine, and murine hypothalamo-hypophyseal neurons contain the homologous cholecystokinins (CCKs). CCK also occurs in neurons innervating bovine melanotrophs. Although the concentration of gastrin is of the same magnitude (15-30 pmol/g) in all neural lobes, the concentration of CCK varies from undetectable in pig and cat to 1 nmol/g in the cow. The constant occurrence of neurohypophyseal gastrin suggests a role different from that of the species-dependent CCK.Keywords
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