Concentration of Clindamycin in Human Bone

Authors:
  • PNPeter Nicholas
    Peter Nicholas
  • BMBurt R. Meyers
    Burt R. Meyers
  • RLRoger N. Levy
    Roger N. Levy

Abstract
Thirty patients undergoing total hip replacement received clindamycin beginning the day before surgery. Mean clindamycin concentrations during surgery were 7.33 ± 3.37 μg/ml in serum and 2.63 ± 1.76 μg/g in bone; mean ratio of bone-serum concentration was 0.40 ± 0.30.