Characteristics of platelet aggregation induced by the monoclonal antibody ALB6 (acute lymphoblastic leukemia antigen p 24)

Authors:
  • CSClaudine Soria
    Claudine Soria
  • MMMassoud Mirshahi
    Massoud Mirshahi
  • JSJeannette Soria
    Jeannette Soria
  • JPJean-Yves Perrot
    Jean-Yves Perrot
  • NFNoëlle Fournier
    Noëlle Fournier
  • MBMartine Billard
    Martine Billard
  • CRClaude Rosenfeld
    Claude Rosenfeld
Publisher website
Google Scholar
Abstract
The leukemia‐associated cell surface antigen p 24 is found on normal platelets as well as on Bernard Soulier syndrome and thrombasthenia type I platelets. ALB6 IgG (a monoclonal antibody against p 24) induces the aggregation of platelets from normal donors but not from thrombasthenia. In contrast, ALB6 Fab inhibits platelet aggregation induced by collagen, ADP, thrombin, ionophore A 23187 and ALB6 IgG. The results suggest that ALB6 interferes with a mechanism common to all aggregation pathways; the possible mechanisms are discussed.

This publication has 13 references indexed in Scilit: