Coumarinolignans Isolated from the Seeds of Brucea javanica

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Abstract
A new coumarinolignan, cleomiscosin E (1), together with the known compound cleomiscosin A (2), has been isolated from the seeds of Brucea javanica (L.) Merr. Their structures were assigned on the basis of spectral studies. These two compounds exhibited potent anti‐inflammatory activities by inhibiting the nitric oxide (NO) production in lipopolysaccharide (LPS)‐activated RAW264.7 macrophages.

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