Molecular Determinants of the Mechanism Underlying Acceleration of the Interaction between Antithrombin and Factor Xa by Heparin Pentasaccharide
Authors:
- James C. WhisstockJames C. Whisstock
- Bernard Le BonniecBBBernard Le Bonniec
- Virginie LouvainVLVirginie Louvain
- Stephen P. BottomleySBStephen P. Bottomley
- Robert N. PikeRPRobert N. Pike
Open Access
- 1 May 2002
- journal article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 277 (18) , 15971-15978
Abstract
No abstract availableKeywords
This publication has 46 references indexed in Scilit:
- Treatment of Proximal Deep Vein Thrombosis With a Novel Synthetic Compound (SR90107A/ORG31540) With Pure Anti–Factor Xa ActivityCirculation, 2000
- Conformational changes in serpins: II. the mechanism of activation of antithrombin by heparinJournal of Molecular Biology, 2000
- Calcium Enhances Heparin Catalysis of the Antithrombin-Factor Xa Reaction by a Template MechanismJournal of Biological Chemistry, 1998
- Conformational Conversion of Antithrombin to a Fully Activated Substrate of Factor Xa without Need for HeparinBiochemistry, 1998
- The anticoagulant activation of antithrombin by heparinProceedings of the National Academy of Sciences, 1997
- Heparin-dependent Modification of the Reactive Center Arginine of Antithrombin and Consequent Increase in Heparin Binding AffinityJournal of Biological Chemistry, 1997
- The coagulation cascade: initiation, maintenance, and regulationBiochemistry, 1991
- Structure-activity relationship in heparin: A synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-factor Xa activityBiochemical and Biophysical Research Communications, 1983
- A simple two-step procedure for the isolation of antithrombin III from biological fluidsThrombosis Research, 1981
- Factor X activating enzyme from Russell's viper venom: isolation and characterizationBiochemistry, 1976