A pivotal role of GSK-3 in synaptic plasticity
Authors:
- Clarrisa A. BradleyCBClarrisa A. Bradley
- Stéphane PeineauSPStéphane Peineau
- Changiz TaghibiglouCTChangiz Taghibiglou
- Celine S. NicolasCNCeline S. Nicolas
- Daniel J. WhitcombDaniel J. Whitcomb
- Zuner A. BortolottoZBZuner A. Bortolotto
- Bong-Kiun KaangBKBong-Kiun Kaang
- Kwangwook ChoKCKwangwook Cho
- Yu Tian WangYWYu Tian Wang
- Graham L. CollingridgeGCGraham L. Collingridge
Open Access
- 1 January 2012
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Molecular Neuroscience
- Vol. 5, 13
Abstract
Glycogen synthase kinase-3 (GSK-3) has many cellular functions. Recent evidence suggests that it plays a key role in certain types of synaptic plasticity, in particular a form of long-term depression (LTD) that is induced by the synaptic activation of N-methyl-D-aspartate receptors (NMDARs). In the present article we summarize what is currently known concerning the roles of GSK-3 in synaptic plasticity at both glutamatergic and GABAergic synapses. We summarize its role in cognition and speculate on how alterations in the synaptic functioning of GSK-3 may be a major factor in certain neurodegenerative disorders.Keywords
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