A Microwave‐Assisted Heck Reaction in Poly(ethylene glycol) for the Synthesis of Benzazepines
- 15 December 2006
- journal article
- research article
- Published by Wiley in European Journal of Organic Chemistry
- Vol. 2007 (1) , 201-208
Abstract
The Heck reaction of alkylated 2‐(trimethylsilyl)ethanesulfonyl (SES)‐protected β‐amino esters provides benzazepines in good yields. Good selectivity towards cyclisation was obtained when the reaction was performed in PEG 3400 as the solvent under microwave activation. Cleavage of the SES group with HF provides the corresponding free benzazepine. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)Keywords
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