Microscopic Margins and Patterns of Treatment Failure in Resected Pancreatic Adenocarcinoma
Authors:
- Samuel R. LukaSLSamuel R. Luka
- Anjali D. DeshpandeADAnjali D. Deshpande
- Bernard J. DubrayBDBernard J. Dubray
- Joshua S. WeirJWJoshua S. Weir
- Danielle H. CarpenterDCDanielle H. Carpenter
- Elizabeth M. BruntEBElizabeth M. Brunt
- Steven M. StrasbergSSSteven M. Strasberg
- William G. HawkinsWHWilliam G. Hawkins
- David C. LinehanDLDavid C. Linehan
Open Access
- 1 August 2012
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Surgery
- Vol. 147 (8) , 753-760
Abstract
Pancreatic cancer is one of the most lethal malignancies.1 Multiple prognostic factors have been identified that are associated with long-term survival,2-7 but positive microscopic resection margins may be the most important independent predictor.8-17 Yeo et al10 demonstrated that patients who underwent pancreaticoduodenectomy (PD) with negative margins had 5-year survival of 26% compared with 8% for those with positive margins. However, recent studies18-23 have found that resection margin status did not affect survival, thus questioning the prognostic significance of positive microscopic margins.Keywords
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