A Homogeneous Fluorescent Live-Cell Assay for Measuring 7-Transmembrane Receptor Activity and Agonist Functional Selectivity Through Beta-Arrestin Recruitment
Authors:
- Bonnie J. HansonBHBonnie J. Hanson
- Justin WetterJWJustin Wetter
- Mark R. BercherMBMark R. Bercher
- Leisha KoppLKLeisha Kopp
- Maya Fuerstenau-SharpMFMaya Fuerstenau-Sharp
- Kevin L. VedvikKVKevin L. Vedvik
- Thomas ZielinskiTZThomas Zielinski
- Chris DoucetteCDChris Doucette
- Pamela J. WhitneyPWPamela J. Whitney
- Chetana RevankarCRChetana Revankar
Open Access
- 1 August 2009
- journal article
- Published by Elsevier in SLAS Discovery
- Vol. 14 (7) , 798-810
Abstract
No abstract availableKeywords
This publication has 20 references indexed in Scilit:
- Antagonism of dopamine D2 receptor/β-arrestin 2 interaction is a common property of clinically effective antipsychoticsProceedings of the National Academy of Sciences, 2008
- β-Arrestins: Multifunctional Cellular MediatorsPhysiology, 2008
- The genetic design of signaling cascades to record receptor activationProceedings of the National Academy of Sciences, 2008
- GPCR functional selectivity has therapeutic impactTrends in Pharmacological Sciences, 2007
- β-Arrestin-biased ligands at seven-transmembrane receptorsTrends in Pharmacological Sciences, 2007
- Collateral efficacy in drug discovery: taking advantage of the good (allosteric) nature of 7TM receptorsTrends in Pharmacological Sciences, 2007
- Transduction of Receptor Signals by ß-ArrestinsScience, 2005
- The Cellular Distribution of Fluorescently Labeled Arrestins Provides a Robust, Sensitive, and Universal Assay for Screening G Protein-Coupled ReceptorsASSAY and Drug Development Technologies, 2002
- The P1′ specificity of tobacco etch virus proteaseBiochemical and Biophysical Research Communications, 2002
- THE ROLE OF RECEPTOR KINASES AND ARRESTINS IN G PROTEIN–COUPLED RECEPTOR REGULATIONAnnual Review of Pharmacology and Toxicology, 1998