Immunohistochemical Detection of the β4 Integrin Subunit in Pancreatic Adenocarcinoma
Authors:
Open Access
- 1 June 2005
- journal article
- research article
- Published by SAGE Publications in Journal of Histochemistry & Cytochemistry
- Vol. 53 (6) , 799-801
Abstract
The expression of the β4 integrin subunit protein in pancreatic cancer was investigated using routine immunohistochemical methods on paraffin-embedded archival material. Forty-eight cases of pancreatic ductal adenocarcinoma were immunostained with a monoclonal antibody to the β4 integrin subunit, and the extent of staining was compared with that seen in non-cancerous pancreatic tissues, including 15 separate cases of chronic pancreatitis and 6 sections from normal pancreas. We found that the β4 integrin subunit protein was overexpressed in the majority of pancreatic carcinoma cases tested, whereas chronic pancreatitis and normal pancreas did not display substantial levels of expression.Keywords
This publication has 8 references indexed in Scilit:
- Cancer Statistics, 2004CA: A Cancer Journal for Clinicians, 2004
- Molecular alterations in pancreatic carcinoma: expression profiling shows that dysregulated expression of S100 genes is highly prevalentThe Journal of Pathology, 2003
- Distinct Distribution of Laminin and Its Integrin Receptors in the PancreasJournal of Histochemistry & Cytochemistry, 2002
- Traction Forces Mediated by α6β4 Integrin: Implications for Basement Membrane Organization and Tumor InvasionMolecular Biology of the Cell, 2001
- The α6β4 integrin and epithelial cell migrationCurrent Opinion in Cell Biology, 2001
- Towards a mechanistic understanding of tumor invasion—lessons from theα 6 β 4integrinSeminars in Cancer Biology, 2001
- Biology and function of hemidesmosomesMatrix Biology, 1999
- Activation of Phosphoinositide 3-OH Kinase by the α6β4 Integrin Promotes Carcinoma InvasionCell, 1997