Synthesis of Highly Substituted Pyridines through Copper‐Catalyzed Condensation of Oximes and α,β‐Unsaturated Imines

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Abstract
A copper‐catalyzed condensation reaction of oxime acetates and α,β‐unsaturated ketimines to give pyridine derivatives is reported. The reaction features mild conditions, high functional‐group compatibility, and high regioselectivity with respect to unsymmetrical oxime acetates, thus allowing the preparation of a wide range of polysubstituted pyridines, many of which are not readily accessible by conventional condensation methods.
Funding Information
  • Ministry of Education - Singapore (RG3/15, RG114/15)
  • Nanyang Technological University

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