Estrogen Deficiency: In Search of Symptom Control and Sexuality

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Abstract
Menopausal symptoms can be very prominent problems in women as they approach the age of 50 years and beyond. For at least three reasons, such problems are exacerbated in patients who have had breast cancer. First, cytotoxic chemotherapy in premenopausal women can cause an abrupt menopause, with marked symptoms. Second, the most commonly used antineoplastic drug in the world, tamoxifen, causes, as its most prominent toxic effect, hot flashes. Third, estrogen therapy, the most widely used treatment of women with menopausal symptoms, is often not used in patients with a history of breast cancer because of concerns about what estrogen might do regarding breast cancer.

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