Transfusion‐associated graft‐versus‐host disease in fludarabine‐treated B‐chronic lymphocytic leukaemia

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Abstract
Summary. Transfusion‐associated graft‐versus‐host disease (TA‐GVHD) is a rare but serious complication of blood component therapy in patients with haematological malignancies. B‐chronic lymphocytic leukaemia (B‐CLL), however, has rarely been associated with TA‐GVHD. We report three patients with advanced B‐CLL who developed TA‐GVHD. All these had been treated with fludarabine. Suppression of T cells by fludarabine may have contributed to an increased susceptibility to TA‐GVHD. The use of irradiated blood products to prevent this complication should be considered for patients with advanced B‐CLL treated with fludarabine or other purine analogues.

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