Discovery of nostatin A, an azole-containing proteusin with prominent cytostatic and pro-apoptotic activity
Open Access
- 22 November 2024
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Organic & Biomolecular Chemistry
- Vol. 23 (2) , 449-460
Abstract
Nostatin A is highly modified ribosomally synthesized and post-translationally modified peptide belonging among proteusins. It inhibits multiple cancer cell lines in nanomolar concentrations and acts via cell cycle arrest and subsequent apoptosis.Keywords
Funding Information
- Grantová Agentura České Republiky (21-05649K)
- Austrian Science Fund (10.55776/I5133)
- Ministerstvo Školství, Mládeže a Tělovýchovy (LM2023042)
- Ministerstvo Školství, Mládeže a Tělovýchovy (CZ.02.1.01/0.0/0.0/18_046/0015974)
- Ministerstvo Školství, Mládeže a Tělovýchovy (CZ.02.01.01/00/22_008/0004624 - Photomachines)
- Akademie Věd České Republiky (68378050-KAV-NPUI)
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