Printable molecule-selective core–shell nanoparticles for wearable and implantable sensing

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Abstract
Wearable and implantable biosensors are pioneering new frontiers in precision medicine by enabling continuous biomolecule analysis for fundamental investigation and personalized health monitoring. However, their widespread adoption remains impeded by challenges such as the limited number of detectable targets, operational instability and production scalability. Here, to address these issues, we introduce printable core–shell nanoparticles with built-in dual functionality: a molecularly imprinted polymer shell for customizable target recognition, and a nickel hexacyanoferrate core for stable electrochemical transduction. Using inkjet printing with an optimized nanoparticle ink formulation, we demonstrate the mass production of robust and flexible biosensors capable of continuously monitoring a broad spectrum of biomarkers, including amino acids, vitamins, metabolites and drugs. We demonstrate their effectiveness in wearable metabolic monitoring of vitamin C, tryptophan and creatinine in individuals with long COVID. Additionally, we validate their utility in therapeutic drug monitoring for cancer patients and in a mouse model through providing real-time analysis of immunosuppressants such as busulfan, cyclophosphamide and mycophenolic acid.
Funding Information
  • National Institutes of Health (R21DK13266, U01CA239373, R01GM129863)
  • American Cancer Society (RSG-21-181-01-CTPS)
  • Office of Naval Research (N00014-21-1-2483, N00014-21-1-2845)
  • Army Research Office (W911NF-23-1-0041)
  • National Aeronautics and Space Administration (80NSSC20M0167)

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