Blood Vessel Morphologic Changes Depicted with MR Angiography during Treatment of Brain Metastases: A Feasibility Study
- 1 December 2007
- journal article
- Published by Radiological Society of North America (RSNA) in Radiology
- Vol. 245 (3) , 824-830
Abstract
Purpose: To prospectively determine if magnetic resonance (MR) angiography can depict intracranial vascular morphologic changes during treatment of brain metastases from breast cancer and if serial quantitative vessel tortuosity measurements can be used to predict tumor treatment response sooner than traditional methods. Materials and Methods: Institutional review board approval and informed consent were obtained for this HIPAA-compliant study. Twenty-two women aged 31–61 years underwent brain MR angiography prior to and 2 months after initiation of lapatinib therapy for brain metastases from breast cancer. Vessels were extracted from MR angiograms with a computer program. Changes in vessel number, radius, and tortuosity were calculated mathematically, normalized with values obtained in 34 healthy control subjects (19 women, 15 men; age range, 19–72 years), and compared with subsequent assessments of tumor volume and clinical course. Results: All patients exhibited abnormal vessel tortuosity at baseline. ...Keywords
This publication has 20 references indexed in Scilit:
- Phase II Trial of Lapatinib for Brain Metastases in Patients With Human Epidermal Growth Factor Receptor 2–Positive Breast CancerJournal of Clinical Oncology, 2008
- Malignancy-associated vessel tortuosity: a computer-assisted, MR angiographic study of choroid plexus carcinoma in genetically engineered mice.2006
- Vessel Tortuosity and Brain Tumor MalignancyAcademic Radiology, 2005
- Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic TherapyScience, 2005
- Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancerNature Medicine, 2004
- Measuring tortuosity of the intracerebral vasculature from MRA imagesIEEE Transactions on Medical Imaging, 2003
- Initialization, noise, singularities, and scale in height ridge traversal for tubular object centerline extractionIEEE Transactions on Medical Imaging, 2002
- Symbolic description of intracerebral vessels segmented from magnetic resonance angiograms and evaluation by comparison with X-ray angiogramsMedical Image Analysis, 2001
- New Guidelines to Evaluate the Response to Treatment in Solid TumorsJNCI: Journal of the National Cancer Institute, 2000
- Tumor Angiogenesis: Therapeutic ImplicationsNew England Journal of Medicine, 1971