Long-Term Efficacy of Trilostane Administered Twice Daily in Dogs With Pituitary-Dependent Hyperadrenocorticism
Authors:
- 1 January 2006
- journal article
- Published by American Animal Hospital Association in Journal of the American Animal Hospital Association
- Vol. 42 (4) , 269-276
Abstract
Trilostane is considered an efficacious and safe medication for canine pituitary-dependent hyperadrenocorticism (PDH). Its recommended frequency of administration is once daily. In this prospective study, the efficacy, toxicity, and long-term outcome of trilostane administered twice daily per os were evaluated in 44 dogs with PDH. Mean initial dose was 3.1 mg/kg q 12 hours, and mean final dose was 3.2 mg/kg q 12 hours. The final total daily dose was lower than previously reported for once-daily administration. The mean survival time for affected dogs was 930 days.Keywords
This publication has 13 references indexed in Scilit:
- Effect of trilostane on serum concentrations of aldosterone, cortisol, and potassium in dogs with pituitary-dependent hyperadrenocorticismAmerican Journal of Veterinary Research, 2004
- Trilostane treatment in dogs with pituitary‐dependent hyperadreno‐corticismAustralian Veterinary Journal, 2003
- Trilostane treatment of a dog with functional adrenocortical neoplasiaJournal of Small Animal Practice, 2003
- Trilostane treatment of 78 dogs with pituitary‐dependent hyperadrenocorticismVeterinary Record, 2002
- Results of clinical examinations, laboratory tests, and ultrasonography in dogs with pituitary-dependent hyperadrenocorticism treated with trilostaneAmerican Journal of Veterinary Research, 2002
- Results of non‐selective adrenocorticolysis by O,p'‐DDD in 129 dogs with pituitary‐dependent hyperadrenocorticismVeterinary Record, 1999
- Mitotane (o, p‘-DDD) Treatment of 200 Dogs with Pituitary-Dependent HyperadrenocorticismJournal of Veterinary Internal Medicine, 1991
- Primary Aldosteronism: Treatment with TrilostaneCardiology, 1985
- Trilostane, an orally active inhibitor of steroid biosynthesisSteroids, 1978
- SPONTANEOUS HYPERADRENOCORTICISM IN THE DOGJournal of Endocrinology, 1968