In vivo inhibition of respiratory syncytial virus by ribavirin
Authors:
- J F HruskaJHJ F Hruska
- P E MorrowPMP E Morrow
- S C SuffinSSS C Suffin
- R G DouglasRDR G Douglas
Open Access
- 1 January 1982
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 21 (1) , 125-130
Abstract
Ribavirin reduced the amount of respiratory syncytial virus in nasal turbinates and lung tissues of experimentally infected cotton rats by over 90%. An effect was seen when the drug was given either intraperitoneally or by aerosol; however, the antiviral effect was achieved at much lower doses when delivered by the aerosol route. No animal deaths due to the drug were seen.Keywords
This publication has 19 references indexed in Scilit:
- Effects of ribavirin on respiratory syncytial virus in vitroAntimicrobial Agents and Chemotherapy, 1980
- Amantadine and ribavirin aerosol treatment of influenza A and B infection in miceAntimicrobial Agents and Chemotherapy, 1980
- Experimental respiratory syncytial virus pneumonia in cebus monkeysJournal of Medical Virology, 1978
- THE RELATIONSHIP BETWEEN THE METABOLISM OF RIBAVIRIN AND ITS PROPOSED MECHANISM OF ACTIONAnnals of the New York Academy of Sciences, 1977
- AEROSOL THERAPY OF INFLUENZA INFECTIONS OF MICE AND PRIMATES WITH RIMANTADINE, RIBAVIRIN, AND RELATED COMPOUNDS *Annals of the New York Academy of Sciences, 1977
- Suppression by 1-β- d -Ribofuranosyl-1,2,4-Triazole-3-Carboxamide (Virazole, ICN 1229) of Influenza Virus-Induced Infections in MiceAntimicrobial Agents and Chemotherapy, 1973
- In Vitro Effect of 1-β- d -Ribofuranosyl-1,2,4-Triazole-3-Carboxamide (Virazole, ICN 1229) on Deoxyribonucleic Acid and Ribonucleic Acid VirusesAntimicrobial Agents and Chemotherapy, 1973
- An Evaluation of a New Antiviral Agent “Virazole” against Influenza Virus InfectionsThe Tohoku Journal of Experimental Medicine, 1973
- Design, synthesis, and broad spectrum antiviral activity of 1-.beta.-D-ribofuranosyl-1,2,4-triazole-3-carboxamide and related nucleosidesJournal of Medicinal Chemistry, 1972
- Broad-Spectrum Antiviral Activity of Virazole: 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamideScience, 1972