Crystal structures of GMP kinase in complex with ganciclovir monophosphate and Ap5G
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This publication has 36 references indexed in Scilit:
- Antiherpesvirus drugs: a promising spectrum of new drugs and drug targetsNature Reviews Drug Discovery, 2003
- Coexpression of Guanylate Kinase with Thymidine Kinase Enhances Prodrug Cell Killing in Vitro and Suppresses Vascular Smooth Muscle Cell Proliferation in VivoMolecular Therapy, 2001
- Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligandsProteins: Structure, Function, and Bioinformatics, 1998
- GanciclovirNew England Journal of Medicine, 1996
- In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain TumorsScience, 1992
- The Purine Path to ChemotherapyScience, 1989
- Stereochemical considerations in the enzymatic phosphorylation and antiviral activity of acyclonucleosides. I. Phosphorylation of 2′-nor-2′-deoxyguanosineBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1987
- 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine: a selective inhibitor of herpes group virus replication.Proceedings of the National Academy of Sciences, 1983
- Unique spectrum of activity of 9-[(1,3-dihydroxy-2-propoxy)methyl]-guanine against herpesviruses in vitro and its mode of action against herpes simplex virus type 1.Proceedings of the National Academy of Sciences, 1983
- 9-(2-Hydroxyethoxymethyl)guanine activity against viruses of the herpes groupNature, 1978