Clonal Chromosomal Abnormalities Showing Multiple-Cell-Lineage Involvement in Acute Myeloid Leukemia

Authors:
  • JGJames D. Griffin
    James D. Griffin
  • CBClara D. Bloomfield
    Clara D. Bloomfield
  • JMJoy Machnicki
    Joy Machnicki
  • ACAlbert de la Chapelle
    Albert de la Chapelle
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Abstract
To determine whether one or more hematopoietic-cell lineages are involved in acute myeloid leukemia (AML), we designed a technique that simultaneously identifies a cell as malignant and determines its lineage. We used numerical clonal chromosomal abnormalities, which are readily detected, to indicate neoplasia, and monoclonal antibodies in an alkaline phosphatase–antialkaline phosphatase detection procedure to identify lineages as granulocytic–monocytic, erythrocytic, or megakaryocytic.

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