A Controlled Trial of Cyclosporine in the Treatment of Primary Biliary Cirrhosis
Authors:
- Jurgen LudwigJLJurgen Ludwig
- Keith D. LindorKLKeith D. Lindor
- Roberta A. JorgensenRJRoberta A. Jorgensen
- William P. BaldusWBWilliam P. Baldus
- Henry A. HomburgerHHHenry A. Homburger
- E. Rolland DicksonEDE. Rolland Dickson
- 17 May 1990
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 322 (20) , 1419-1424
Abstract
Primary biliary cirrhosis is a progressive disease of the liver characterized by the immunologic destruction of bile ducts; effective therapy is lacking. We therefore evaluated the safety and efficacy of low-dose cyclosporine in 29 patients with primary biliary cirrhosis without evidence of damage to the lobular architecture (precirrhotic disease) or portal hypertension. The patients were randomly assigned to receive either cyclosporine (4 mg per kilogram of body weight per day) or placebo.Keywords
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