Circadian Rhythm in Pineal Serotonin: Effect of Monoamine Oxidase Inhibition and Reserpine
Authors:
- 30 July 1965
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 149 (3683) , 542-544
Abstract
The pineal gland of the rat shows a circadian rhythm in its serotonin content, the amount of serotonin decreasing at night. This decrease can be prevented by inhibiting the action of monoamine oxidase. Reserpine abolishes the circadian rhythm in pineal serotonin in the same manner as does interruption of the sympathetic nervous connections of the central nervous system and the pineal gland. These observations suggest that circadian changes in release and binding of serotonin may occur in the pineal gland, and that a central mechanism in which monoamines participate may control the circadian pineal-serotonin rhythm.Keywords
This publication has 15 references indexed in Scilit:
- A sensitive and specific fluorescence assay for tissue serotoninBiochemical Pharmacology, 1965
- Serotonin Rhythm in the Pineal Organ: Control by the Sympathetic Nervous SystemScience, 1964
- Control of the circadian rhythm in serotonin content of the rat pineal glandLife Sciences, 1964
- A sensitive assay for 5-hydroxytryptophan decarboxylaseBiochemical Pharmacology, 1964
- A sensitive and specific assay for the estimation of monoamine oxidaseBiochemical Pharmacology, 1963
- Melatonin Synthesis in the Pineal Gland: Control by LightScience, 1963
- Melatonin, a Pineal Substance: Effect on the Rat OvaryScience, 1963
- Reduction of mammalian pineal weight and lipid during continuous lightGeneral and Comparative Endocrinology, 1961
- Serotonin Release as a Possible Mechanism of Reserpine ActionScience, 1955
- Effect of continuous light on periodic spontaneous activity of white‐footed mice (Peromyscus)Journal of Experimental Zoology, 1939