Missed connections: recombination and human aneuploidy
Authors:
- 23 January 2021
- journal article
- review article
- Published by Wiley in Prenatal Diagnosis
- Vol. 41 (5) , 584-590
Abstract
The physical exchange of DNA between homologs, crossing‐over, is essential to orchestrate the unique, reductional first meiotic division (MI). In females, the events of meiotic recombination that serve to tether homologs and facilitate their disjunction at MI occur during fetal development, preceding the MI division by several decades in our species. Data from studies in humans and mice demonstrate that placement of recombination sites during fetal development influences the likelihood of an MI nondisjunction event that results in the production of an aneuploid egg. Here we briefly summarize what we know about the relationship between aneuploidy and meiotic recombination and important considerations for the future of human assisted reproduction.Keywords
Funding Information
- National Institutes of Health (R01 ES013527, R37 HD21341)
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