Partial purification of rabbit aorta contracting substance-releasing factor and inhibition of its activity by anti-inflammatory steroids
Authors:
- F. P. NijkampFNF. P. Nijkamp
- R. J. FlowerRFR. J. Flower
- S. MoncadaSMS. Moncada
- J. R. VaneJVJ. R. Vane
- 1 October 1976
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 263 (5577) , 479-482
Abstract
Rabbit aorta contracting substance-releasing factor (RCS-RF) is found in perfusates from guinea pig lungs during anaphylaxis. It has been identified as a small peptide which releases arachidonic acid from lung tissue, thus generating prostaglandin endoperoxides and tbromboxanes and causing bronchocconstriction. Anti-inflammatory steroids block the release of arachidonate by RCS-RF. In this activity their relative potency is very similar to their relative anti-inflammatory potency, suggesting that the two actions may be related.Keywords
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