Curcumin protects against rotenone-induced Parkinson's disease in mice by inhibiting microglial NLRP3 inflammasome activation and alleviating mitochondrial dysfunction
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This publication has 56 references indexed in Scilit:
- Neuroinflammation in the pathophysiology of Parkinson’s disease and therapeutic evidence of anti-inflammatory drugsArquivos de Neuro-Psiquiatria, 2015
- Curcumin as a putative antidepressantExpert Review of Neurotherapeutics, 2015
- Meta-analyses on prevalence of selected Parkinson’s nonmotor symptoms before and after diagnosisTranslational Neurodegeneration, 2015
- Alzheimer’s disease: current and future therapyExpert Review of Neurotherapeutics, 2015
- An update on the rotenone models of Parkinson's disease: Their ability to reproduce the features of clinical disease and model gene–environment interactionsNeuroToxicology, 2015
- Inflammasomes: Molecular Regulation and Implications for Metabolic and Cognitive DiseasesMolecules and Cells, 2014
- Liposomal-formulated curcumin [Lipocurc™] targeting HDAC (Histone Deacetylase) prevents apoptosis and improves motor deficits in Park 7 (DJ-1)-knockout rat model of Parkinson’s disease: implications for epigenetics-based nanotechnology-driven drug platformJournal of Complementary and Integrative Medicine, 2013
- Mitochondrial complex I inhibitor rotenone-induced toxicity and its potential mechanisms in Parkinson’s disease modelsCritical Reviews in Toxicology, 2012
- Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanismCarcinogenesis, 2007
- Subcutaneous Rotenone Exposure Causes Highly Selective Dopaminergic Degeneration and α-Synuclein AggregationExperimental Neurology, 2003