Laterality, heterotaxy, and isolated congenital heart defects
Authors:
Open Access
- 13 August 2024
- journal article
- research article
- Published by Springer Nature in Genome Medicine
- Vol. 16 (1) , 1-3
Abstract
To date, the role of NODAL in normal and abnormal L-R asymmetry has been well established. In a recent paper, mutations of this gene have been reported in heterotaxy but also in transposition with D- or L-ventricular loop. The effects of NODAL and other laterality genes can be recognized separately in all three cardiac segments: for topology and septation of the atria, for ventricular looping, and for spiralization and alignment of the great arteries.Keywords
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