RELATIONSHIP BETWEEN CEREBRAL ENERGY FAILURE AND FREE FATTY ACID ACCUMULATION FOLLOWING PROLONGED BRAIN ISCHEMIA
Authors:
- Junji KuwashimaJKJunji Kuwashima
- Keiji NakamuraKNKeiji Nakamura
- Buichi FujitaniBFBuichi Fujitani
- Toshiaki KadokawaTKToshiaki Kadokawa
- Kouichi YoshidaKYKouichi Yoshida
- Masanao ShimizuMSMasanao Shimizu
Open Access
- 1 January 1978
- journal article
- research article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 28 (2) , 277-287
Abstract
Prolonged ischemia by bilateral carotid artery ligation in rats resulted in cerebral edema with a reduced energy state. Mitochondria isolated from the ischemic brain showed an impairment of oxidative phosphorylation. The ischemic brain was also characterized by a remarkable accumulation of free fatty acids known to have properties as an uncoupling factor. The major components of increased free fatty acids were palmitic, stearic, oleic and arachidonic acids. The analysis of saponified myelin and mitochondrial lipids from the ischemic brain showed a decrease in fatty acid contents. The main components of decreased fatty acids in these subcellular fractions corresponded to those of free fatty acids accumulating in the ischemic brain. Cerebral energy failure in the ischemic brain is related to the accumulation of free fatty acids, which are derived from endogenous brain lipids.Keywords
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