Indanone Building Blocks from Lignin Related C-9 Plaform Molecules

Authors:
Preprint
Publisher website
Google Scholar
Abstract
Lignin-based aryl 3-hydroxypropanones were converted into indanones via domino dehydration/Nazarov cyclization in the presence of a superacid. The cyclization was studied in detail, and the resulting indanones were engaged in two postfunctionalizations: a reduction/elimination domino sequence and a ring expansion. Lastly, the method has been successfully applied to the synthesis of the anti-Alzheimer drug donepezil.
Funding Information
  • Agence Nationale de la Recherche (ANR-22-CE92-0067-01)
  • Deutsche Forschungsgemeinschaft (505782409)