Identification of a cDNA Encoding a Long Form of Prolactin Receptor in Human Hepatoma and Breast Cancer Cells
Authors:
- Marc EderyMEMarc Edery
- Mariko ShirotaMSMariko Shirota
- Christine JolicoeurCJChristine Jolicoeur
- Laurence LesueurLLLaurence Lesueur
- Suhad AliSASuhad Ali
- David GouldDGDavid Gould
- Jean DjianeJDJean Djiane
- Paul A. KellyPKPaul A. Kelly
- 1 September 1989
- journal article
- research article
- Published by The Endocrine Society in Molecular Endocrinology
- Vol. 3 (9) , 1455-1461
Abstract
Human PRL receptor cDNA clones from hepatoma (Hep G2) and breast cancer (T-47D) libraries were isolated by using a rat PRL receptor cDNA probe. The nucleotide sequence predicts a mature protein of 598 amino acids with a much longer cytoplasmic domain than the rat liver PRL receptor. Although this extended region has additional segments of localized sequence identity with the human GH receptor, there is no identity with any consensus sequences known to be involved in hormonal signal transduction. This cDNA will be a valuable tool to better understand the role of PRL in the development and growth of human breast cancer.Keywords
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