Localization matters: a nuclear targeting two-photon absorption iridium complex in photodynamic therapy

Authors:
Publisher website
Google Scholar
Abstract
We present a two-photon (2P, 800 nm) PDT cyclometalated Iridium(III) complex (Ir-Es) that targets the intracellular nucleus. The complex is capable of migrating sequentially from the nucleus to mitochondria and inducing dual-damage under light exposure. This study suggests that with minor modification of the terminal moieties of complexes, their final intracellular destinations and PDT efficiency can be significantly impacted.
Funding Information
  • National Natural Science Foundation of China (21602003, 51372003, 21271004, 51432001, and 514720)

This publication has 34 references indexed in Scilit: