Melanocortin-4 Receptor Gene Variants and Weight Change Following Switch to Integrase Inhibitor-Based Antiretroviral Therapy

Authors:
Open Access
Publisher website
Google Scholar
Abstract
Given the melanocortin-4 receptor's (MC4R) importance in obesity, we examined associations between MC4R gene variants and weight following a switch to integrase inhibitor-containing antiretroviral therapy among participants in Advancing Clinical Therapeutics Globally studies. Among 529 persons with HIV (median age: 50 years, 29% non-Hispanic Black, 22% female), 62% were overweight or obese at integrase strand transfer inhibitor switch, and 62% switched to raltegravir. In adjusted linear models, three variants were associated (P < .05) with weight change after switch in all participants or in prespecified subgroups. These exploratory findings are consistent with the role of melanocortins in appetite and weight and suggest a neuroendocrine contribution to integrase inhibitor-related weight gain.
Funding Information
  • National Institutes of Health (UM1 AI068634, UM1 AI068636, UM1 AI106701)
  • National Center for Research Resources
  • National Center for Advancing Translational Sciences (AI110527, AI077505, TR000445, AI069439)
  • Tennessee Center for AIDS Research ((P30) AI110527)
  • ACTG (A5095, A5142, A5202)
  • National Institutes of Health (A1069412, A1069423, A1069424, A1069503, AI025859, AI025868, AI027658, AI027666, AI027675, AI032782, AI034853, AI038858, AI045008, AI046370, AI046376, AI050409, AI050410, AI058740, AI060354, AI069412, AI069415, AI069418, AI069419, AI069423, AI069424, AI069428, AI069432, AI069434, AI069439, AI069447, AI069450, AI069452, AI069465, AI069467, AI069470, AI069471, AI069472, AI069474, AI069477, AI069481, AI069484, AI069494, AI069495, AI069496, AI069501, AI069502, AI069503, AI069511, AI069513, AI069532, AI069534, AI069556, AI072626, AI073961, RR000046, RR000425, RR023561, RR024156, RR024160, RR024996, RR025008, RR025747, RR025777, RR025780, TR000004, TR000058, TR000124, TR000170, TR000439, TR000457, TR001079, TR001082, TR001111, TR024160)

This publication has 53 references indexed in Scilit: