Discovery of diazepane amide DORAs and 2-SORAs enabled by exploration of isosteric quinazoline replacements

This publication has 27 references indexed in Scilit:

• International Union of Basic and Clinical Pharmacology. LXXXVI. Orexin Receptor Function, Nomenclature and Pharmacology
  Pharmacological Reviews, 2012
• Orexin Receptor Antagonism, a New Sleep-Enabling Paradigm: A Proof-of-Concept Clinical Trial
  Clinical Pharmacology & Therapeutics, 2012
• Orexin receptors as therapeutic drug targets
  2012
• Connectomics of orexin-producing neurons: interface of systems of emotion, energy homeostasis and arousal
  Trends in Pharmacological Sciences, 2011
• Hypocretin Antagonists in Insomnia Treatment and Beyond
  Current Pharmaceutical Design, 2011
• Orexin Receptors: Pharmacology and Therapeutic Opportunities
  Annual Review of Pharmacology and Toxicology, 2011
• The brain hypocretins and their receptors: mediators of allostatic arousal
  Current Opinion in Pharmacology, 2009
• Promotion of sleep by targeting the orexin system in rats, dogs and humans
  Nature Medicine, 2007
• Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior
  Cell, 1998
• The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
  Proceedings of the National Academy of Sciences, 1998