Biomarkers of liver failure in mechanical jaundice as preclinical indicators reflecting the development of the pathological process

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Abstract
The issue of liver failure arising from mechanical jaundice is a pressing issue for intensive care. The main goals of treatment are to replace and maintain liver function, prevent or minimize the development of secondary complications from organs and systems. Traditionally, a range of different methods is used in the diagnosis of liver failure arising from mechanical jaundice, ranging from instrumental, biochemical, serological, immunological, to the most complex molecular biological studies. However, generally accepted indicators do not always reflect the depth of damage to the liver parenchyma and the severity of the pathological process, which requires a search for specific markers of liver damage as indicators of the severity of the patient's condition and predictors of the outcome of the disease. Potential candidates should have high topical diagnostics, specificity and sensitivity in the first hours of the disease. According to the literature, the following biomarkers of liver injury potentially meet these requirements: liver form of fatty acid binding protein, 5-nucleotidase, liver arginase, hyaluronic acid. However, we believe that the issue of their reliability for assessing the condition of patients and predicting the outcome of liver failure against the background of mechanical jaundice remains insufficiently studied, which necessitates further research.

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