Sodium-Lump-Mediated Mechanochemical Deprotection of Benzyl-Derived Groups

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Abstract
This study demonstrates the facile removal of benzyl-derived protecting groups via ammonia-free, mechanochemically driven Birch reduction using inexpensive and easy-to-handle sodium lumps. Various benzyl-protected alcohols and amines were efficiently deprotected within 30 min. Notably, all synthetic operations can be performed without inert gases or bulk solvents.
Funding Information
  • Japan Science and Technology Corporation (JPMJCR19R1,JPMJFR201I)
  • Japan Society of Physiological Anthropology (22H00318,22K18333,24H00453,24H01050,24H01832)

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