Protective Role of Glutathione against Peroxynitrite-Mediated DNA Damage During Acute Inflammation

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Abstract
Inflammation is an immune response to protect against various types of infections. When unchecked, acute inflammation can be life-threatening, as seen with the current corona virus pandemic. Strong oxidants, such as peroxynitrite produced by immune cells, are major mediators of the inflammation-associated pathogenesis. Cellular thiols play important roles in mitigating inflammation-associated macromolecular damage including DNA. Herein, we have demonstrated a role of glutathione (GSH) and other thiols in neutralizing the effect of peroxynitrite-mediated DNA damage through stable GSH-DNA adduct formation. Our observation supports the use of thiol supplements as a potential therapeutic strategy against severe Covid-19 cases and a Phase II (NCT04374461) open-label clinical trial launched in early May 2020 by the Memorial Sloan Kettering Cancer Center.
Funding Information
  • National Institute of Environmental Health Sciences (R01 ES010546)
  • Anusandhan National Research Foundation (ECR/2015/000197, ECR/2015/000198)
  • Department of Biotechnology , Ministry of Science and Technology (BT/RLF/RE-ENTRY/18/2013, BT/RLF/RE-ENTRY/35/2012)

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