Preservation of the substanitia nigra and locus coeruleus in a patient receiving levodopa (2 kg) plus decarboxylase inhibitor over a four‐year period
Authors:
- 1 January 1986
- journal article
- case report
- Published by Wiley in Movement Disorders
- Vol. 1 (1) , 65-68
Abstract
A 72‐year‐old hypertensive man developed parkinsonism and was treated with Sinemet for 4 years but then died of a bronchial carcinoma. Necropsy revealed cerebrovascular disease and amyloid angiopathy. The substantia nigra and locus coeruleus were normal on light microscopy.Keywords
This publication has 6 references indexed in Scilit:
- Congophilic angiopathy of the brain: a clinical and pathological report on two siblings.Journal of Neurology, Neurosurgery & Psychiatry, 1982
- Long‐term administration of L‐DOPA does not damage dopaminergic neurons in the mouseNeurology, 1981
- Evidence to support early levodopa therapy in Parkinson diseaseNeurology, 1981
- Analysis of the clinical problems in parkinsonism and the complications of long‐term levodopa therapyNeurology, 1979
- Autoxidation versus Covalent Binding of Quinones as the Mechanism of Toxicity of Dopamine, 6-Hydroxydopamine, and Related Compounds toward C1300 Neuroblastoma Cells in VitroMolecular Pharmacology, 1978
- Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine systemBrain Research, 1970