Diversity and structure of genes of the α family of mouse T-cell antigen receptor
Authors:
- Bernhard ArdenBABernhard Arden
- Joan L. KlotzJKJoan L. Klotz
- Gerald SiuGSGerald Siu
- Leroy E. HoodLHLeroy E. Hood
- 1 August 1985
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 316 (6031) , 783-787
Abstract
We have analysed 19 complementary DNA clones encoding the alpha-chain of the T-cell antigen receptor derived from thymic transcripts, and find that 15 of them contain partial or complete variable (V alpha) genes. Seven of these genes cross-hybridize to over 40 germline V alpha gene segments in Southern blot analyses. Of the 19 joining (J alpha) sequences examined, 18 seem to be encoded by distinct gene segments, hence the repertoire of J alpha gene segments is much larger than those of the immunoglobulin or T-cell receptor beta-chain gene families. We suggest that the variable domains of immunoglobulins and T-cell antigen receptors are similar in structure.Keywords
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