Lung proinflammatory microRNA and cytokine expression in a mouse model of allergic inflammation: role of sex chromosome complement and gonadal hormones
- 1 February 2024
- journal article
- research article
- Published by American Physiological Society in Physiological Genomics
- Vol. 56 (2) , 179-193
Abstract
MiRNAs play important roles in regulating gene and environmental interactions. However, their role in mediating sex differences in allergic responses and lung diseases has not been elucidated. Our study used a targeted omics approach to characterize the contributions of gonadal hormones and chromosomal components to lung responses to an allergen challenge. Our results point to the influence of sex hormones in miRNA expression and proinflammatory markers in allergic airway inflammation.Keywords
Funding Information
- HHS | NIH | National Heart, Lung, and Blood Institute (R01HL159764)
- HHS | NIH | National Heart, Lung, and Blood Institute (3R01HL159764-02S1)
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