Single-molecule force spectroscopy of ligand–receptor mechanics at extracellular vesicle biointerfaces
Open Access
- 4 November 2026
- journal article
- Published by Royal Society of Chemistry (RSC) in Journal of Materials Chemistry B
- Vol. 14 (42) , 13092-13101
Abstract
AFM force spectroscopy distinguishes ligand accessibility from rupture mechanics on extracellular vesicles. EpCAM–antibody interactions tend to show higher apparent off-rates than ITG–cRGD and GPC1–antibody interactions.Keywords
Funding Information
- National Science Foundation (CBET 2317111)
- National Institutes of Health (R01AG056881)
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