Normalization of array-CGH data: influence of copy number imbalances
Open Access
- 1 January 2007
- journal article
- research article
- Published by Springer Nature in BMC Genomics
- Vol. 8 (1) , 382
Abstract
High-resolution microarray-based comparative genomic hybridization (CGH) techniques have successfully been applied to study copy number imbalances in a number of settings such as the analysis of cancer genomes. For normalization of array-CGH data, methods initially developed for gene expression microarray analysis have, in general, been directly adopted and used. However, these methods are designed to work under assumptions that may not be valid for array-CGH data when copy number imbalances are present. We therefore sought to investigate the effect on normalization imposed by copy number imbalances.Keywords
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