Effect of lysophosphatidic acid on the preimplantation development of mouse embryos
Authors:
- Shuji YamanoSYShuji Yamano
- Shinji MurayamaSMShinji Murayama
- Hiromi IshikawaHIHiromi Ishikawa
- Akira TokumuraATAkira Tokumura
- Toshihiro AonoTAToshihiro Aono
- 29 August 1994
- journal article
- Published by Wiley in FEBS Letters
- Vol. 351 (1) , 38-40
Abstract
The effect of lysophosphatidic acid (LPA) on the preimplantation development of mouse embryos was examined. The blastocyst rates from 2‐cell and 4‐cell stage embryos were significantly higher in the presence of LPA at the pronuclear stage. However, the blastocyst rate from 4‐cell stage embryos was significantly lower when LPA was added to the medium at the 4‐cell stage than when it was added at the pronuclear stage. Furthermore, pretreatment of pronuclear stage embryos with pertussis toxin suppressed LPA‐induced embryo development, suggesting that it is probably mediated by a Gi‐protein‐linked receptor.Keywords
This publication has 16 references indexed in Scilit:
- Signalling properties of lysophosphatidic acidTrends in Pharmacological Sciences, 1993
- Mediation of the actions of insulin and insulin‐like growth factor‐1 on preimplantation mouse embryos in vitroMolecular Reproduction and Development, 1992
- Phosphatidic acid and lysophosphatidic acid stimulate receptor-regulated membrane currents in the Xenopus laevis oocyteArchives of Biochemistry and Biophysics, 1992
- Lysophosphatidic acid induces inward currents in Xenopuslaevis oocytes; evidence for an extracellular site of actionEuropean Journal of Pharmacology, 1992
- Insulin‐like growth factor‐1 stimulates growth of mouse preimplantation embryos in vitroMolecular Reproduction and Development, 1992
- Preimplantation embryo development in vitro: cooperative interactions among embryos and role of growth factors.Proceedings of the National Academy of Sciences, 1990
- Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteinsCell, 1989
- INSULIN STIMULATES PROTEIN SYNTHESIS IN COMPACTED MOUSE EMBRYOSEndocrinology, 1988
- Involvement of lysophospholipase D in the production of lysophosphatidic acid in rat plasmaBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1986
- Cytoplasmic control of preimplantation development in vitro in the mouseNature, 1982