Differential effect of inhibitory strategies of the V617 mutant of JAK2 on cytokine receptor signaling
- 1 July 2019
- journal article
- research article
- Published by Elsevier in Journal of Allergy and Clinical Immunology
- Vol. 144 (1) , 224-235
Abstract
No abstract availableKeywords
Funding Information
- FRS-FNRS
- WELBIO
- Télévie
- Ludwig Institute for Cancer Research
- FRS-FNRS
- de Duve Institute
- WELBIO
This publication has 50 references indexed in Scilit:
- Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617FNature Structural & Molecular Biology, 2012
- Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAFProceedings of the National Academy of Sciences, 2011
- The Constitutive Activation of Jak2-V617F Is Mediated by a π Stacking Mechanism Involving Phenylalanines 595 and 617Biochemistry, 2010
- Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitorsNature, 2010
- JAK mutations in high-risk childhood acute lymphoblastic leukemiaProceedings of the National Academy of Sciences, 2009
- Ligand-independent Homomeric and Heteromeric Complexes between Interleukin-2 or -9 Receptor Subunits and the γ ChainJournal of Biological Chemistry, 2008
- Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemiaJournal of Experimental Medicine, 2008
- JAK2Exon 12 Mutations in Polycythemia Vera and Idiopathic ErythrocytosisNew England Journal of Medicine, 2007
- JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation modelBlood, 2006
- A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia veraNature, 2005