Effect of Continuous Positive Airway Pressure on Blood Pressure
- 1 January 2000
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Hypertension
- Vol. 35 (1) , 144-147
Abstract
—This study examined the effect of continuous positive airway pressure (CPAP) treatment on blood pressure in patients with obstructive sleep apnea. Thirty-nine patients with sleep apnea were studied. Ambulatory blood pressure monitoring was obtained before and after patients were randomized to receive either 1 week of CPAP or placebo CPAP (CPAP administered at ineffective pressure). Blood pressure was examined over daytime hours (6 am to 10 pm ) and during nighttime hours (10 pm to 6 am ). Daytime mean arterial blood pressure decreased significantly but equally in both the active treatment group and the placebo treatment group ( P =0.001). Nighttime mean arterial pressure levels decreased to a much greater extent over time in the patients who received active CPAP treatment ( P =0.032). CPAP does appear to decrease nighttime blood pressure. However, the decrease in daytime blood pressure may reflect a nonspecific response (ie, placebo), since both the active treatment group and the placebo treatment group developed comparable decreases in blood pressure.Keywords
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