Avascular necrosis of bone in children undergoing allogeneic bone marrow transplantation
Abstract
Avascular necrosis of bone (AVNB) is reported in two children after allogeneic bone marrow transplantation. Preparation therapy for transplantation included cyclophosphamide and total body irradiation. Corticosteroids, cyclosporine A, and methotrexate were used for graft-versus-host-disease prophylaxis. The possible role of combination therapy in development of AVNB is discussed, but a direct relationship with single agents was not found. However, an early diagnosis is important to institute conservative treatment and prevent irreversible damage to affected joints. Magnetic resonance imaging was found to be more sensitive than plain radiography in early detection of AVNB.Keywords
This publication has 17 references indexed in Scilit:
- The controversy of core decompression of the femoral head for osteonecrosisArthritis & Rheumatism, 1989
- Response: The role of core decompression in the treatment of ischemic necrosis of the femoral headArthritis & Rheumatism, 1989
- Bone marrow magnetic resonance studies in childhood leukemia. Evaluation of osteonecrosisCancer, 1987
- ACROSS-STUDY EVALUATION OF ASSOCIATION BETWEEN STEROID DOSE AND BOLUS STEROIDS AND AVASCULAR NECROSIS OF BONEThe Lancet, 1987
- Avascular necrosis of bone following combination chemotherapy for acute lymphocytic leukemiaMedical and Pediatric Oncology, 1985
- Early diagnosis and treatment of steroid induced avascular necrosis of bone.BMJ, 1984
- Avascular necrosis of bone caused by combination chemotherapy without corticosteroids.BMJ, 1984
- Avascular necrosis of bone in children receiving high-dose steroid treatment.BMJ, 1980
- II. THE TREATMENT OF ISCHEMIC NECROSIS OF BONE IN SYSTEMIC LUPUS ERYTHEMATOSUSMedicine, 1980
- ASEPTIC NECROSIS OF BONE FOLLOWING RENAL TRANSPLANTATIONMedicine, 1978