Dopamine-Mediated Zwitterionic Polyelectrolyte-Coated Polypropylene Hernia Mesh with Synergistic Anti-inflammation Effects

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Abstract
Over twenty million ventral hernia repairs are performed worldwide annually and only a minority (＜10 %) of cases are not mesh-based. However, even polypropylene (PP), endorsed as the “gold standard” of all prosthetic materials used in this field, is still subject to many complications caused by the foreign body reaction (FBR). Here, we describe the build-up of dopamine-mediated zwitterionic poly (sulfobetaine methacrylate) (PSBMA) coatings to inhibit non-specific protein adsorption. Based on the universal adhesive ability of polydopamine (PDA), PSBMA has been coated on the PP mesh surface via two strategies: sequential deposition (PSBMA-PDA-PP) and co-deposition ([email protected]). The presence of PSBMA shows great contribution to obviously decreased hydrophobicity of PP surface (WCAco = 36.3o and WCAseq = 30.7o) as well as improved protein resistance (Reductionco = 74 % and Reductionseq = 82 %). Notably, as the intermedia between PP and PSBMA, PDA can endow PP mesh with antioxidant activity, further featuring with synergistic anti-inflammation therapeutic effect when coupling with PSBMA. With almost equal surface content of PSBMA, the PSBMA-PDA-PP exhibited a more superior ability against macrophages adhesion and proliferation, and showed more significantly decreased releases of TNF-α and IL-6 (p < 0.05) than those of [email protected], fundamentally attributed to its more neutral surface potential and the protection for polyphenols of PDA from oxidation with PSBMA as the outer-layer. Furthermore, the coating layers demonstrated a good stability and no sacrifice of pristine mechanical property. The proposed dopamine-mediated PSBMA coatings possesses high potential in biomedical implants area for attenuating FBR.
Funding Information
  • the Fundamental Research Funds for the Central Universities (2232020G-01)

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