Review: Tissue remodeling and angiogenesis in asthma: the role of the eosinophil
Open Access
- 1 June 2008
- journal article
- review article
- Published by SAGE Publications in Therapeutic Advances in Respiratory Disease
- Vol. 2 (3) , 163-171
Abstract
This review covers the role of eosinophils in asthma-associated tissue remodeling and angiogenesis focusing on angiogenesis which is a recently discovered feature of asthma. In addition, novel directions for eosinophil-targeted/angiogenesis-targeted pharmacological intervention are discussed as new approaches in the treatment of asthma.Keywords
This publication has 70 references indexed in Scilit:
- Angiogenesis in life, disease and medicineNature, 2005
- Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapyBiochemical and Biophysical Research Communications, 2005
- Airway wall remodelling: the influence of corticosteroidsCurrent Opinion in Allergy and Clinical Immunology, 2005
- Regulation of angiogenesis by hypoxia: role of the HIF systemNature Medicine, 2003
- Effects of Inhaled Corticosteroids, Leukotriene Receptor Antagonists, or Both, Plus Long-Acting ??2-Agonists on Asthma PathophysiologyDrugs, 2003
- Myofibroblasts and mechano-regulation of connective tissue remodellingNature Reviews Molecular Cell Biology, 2002
- Quantitative and morphological analysis of the vascular bed in bronchial biopsy specimens from asthmatic and non-asthmatic subjectsThorax, 2001
- Nerve growth factor is preformed in and activates human peripheral blood eosinophilsJournal of Allergy and Clinical Immunology, 1998
- Expression of transforming growth factors-α and β1 messenger RNA and product by eosinophils in nasal polypsJournal of Allergy and Clinical Immunology, 1994
- Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growthNature, 1990