Independent Origin of IFN-α and IFN-β in Birds and Mammals
- 1 August 2000
- journal article
- research article
- Published by SAGE Publications in Journal of Interferon & Cytokine Research
- Vol. 20 (8) , 737-739
Abstract
Phylogenetic analysis of type I interferon (IFN) from birds and mammals strongly supported the hypothesis that the gene duplication giving rise to the α and β families of mammalian IFN occurred after the divergence of birds from mammals, whereas the bird IFN that have been designated α and β duplicated independently in the avian lineage. Therefore, IFN designated α and β in birds are not orthologous to those similarly designated in mammals.Keywords
This publication has 18 references indexed in Scilit:
- The Type I Interferon Receptor: Structure, Function, and Evolution of a Family BusinessJournal of Interferon & Cytokine Research, 1999
- The Evolution of the Type I Interferons1Journal of Interferon & Cytokine Research, 1998
- Structure of the chicken interferon-γ gene, and comparison to mammalian homologuesGene, 1998
- New and Atypical Families of Type I Interferons in Mammals: Comparative Functions, Structures, and Evolutionary Relationships11997
- A Family of Genes Coding for Two Serologically Distinct Chicken InterferonsJournal of Biological Chemistry, 1996
- CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choiceNucleic Acids Research, 1994
- Chicken Interferon Gene: Cloning, Expression, and AnalysisJournal of Interferon Research, 1994
- Convergent evolution: the need to be explicitTrends in Biochemical Sciences, 1994
- The involvement of NF-κB in β-interferon gene regulation reveals its role as widely inducible mediator of signal transductionCell, 1989
- On the Problem of Discovering the Most Parsimonious TreeThe American Naturalist, 1977