Cell-based analysis of Chikungunya virus E1 protein in membrane fusion
Open Access
- 21 April 2012
- journal article
- research article
- Published by Springer Nature in Journal of Biomedical Science
- Vol. 19 (1) , 44
Abstract
Chikungunya fever is a pandemic disease caused by the mosquito-borne Chikungunya virus (CHIKV). E1 glycoprotein mediation of viral membrane fusion during CHIKV infection is a crucial step in the release of viral genome into the host cytoplasm for replication. How the E1 structure determines membrane fusion and whether other CHIKV structural proteins participate in E1 fusion activity remain largely unexplored.Keywords
This publication has 39 references indexed in Scilit:
- The Domain I-Domain III Linker Plays an Important Role in the Fusogenic Conformational Change of the Alphavirus Membrane Fusion ProteinJournal of Virology, 2011
- Chikungunya virus emergence is constrained in Asia by lineage-specific adaptive landscapesProceedings of the National Academy of Sciences, 2011
- Glycoprotein organization of Chikungunya virus particles revealed by X-ray crystallographyNature, 2010
- Structural changes of envelope proteins during alphavirus fusionNature, 2010
- Dealing with low pH: entry and exit of alphaviruses and flavivirusesTrends in Microbiology, 2009
- Comparative full genome analysis revealed E1: A226V shift in 2007 Indian Chikungunya virus isolatesVirus Research, 2008
- The Inactive 44-kDa Processed Form of Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Enhances Proteolytic Activity via Regulation of Endocytosis of Active MT1-MMPJournal of Biological Chemistry, 2008
- Conformational change and protein–protein interactions of the fusion protein of Semliki Forest virusNature, 2004
- Membrane fusion process of Semliki Forest virus. I: Low pH-induced rearrangement in spike protein quaternary structure precedes virus penetration into cells.Journal of Cell Biology, 1992
- Studies on the mechanism of membrane fusion: site-specific mutagenesis of the hemagglutinin of influenza virus.Journal of Cell Biology, 1986