Synthesis and antithrombogenicity of anionic polyurethanes and heparin‐bound polyurethanes

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Abstract
Two kinds of novel antithrombogenic polyurethane materials were synthesized. One of them is a polyetherurethane with anionic charges on the film surface, and the other is a polyetherurethaneurea to which heparin was covalently bound. The mechanism of their antithrombogenicity was investigated. The anionic polyetherurethane selectively adsorbed albumin, did not cause a conformational change of plasma proteins adsorbed, and suppressed the adherence and deformation of platelets but did not deactivate the blood–clotting system, thus leading to a moderate antithrombogenicity. The heparin‐bound polyetherurethaneurea was not favorable for the selective adsorption of albumin, caused the denaturation of plasma proteins adsorbed, and induced the adherence and deformation of platelets but deactivated the blood‐clotting system, leading to excellent antithrombogenicity. For the investigation of blood‐material interaction, the importance of a multiparameter estimation of the activation of platelets and the blood‐clotting system was indicated.

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