Ultrastructure of the Stroma of Nasal Polyps: Cilia in Stromal Fibroblasts

Authors:
  • ABAnthony Busuttil
    Anthony Busuttil
  • IMIan A. R. More
    Ian A. R. More
  • DMDavid McSeveney
    David McSeveney
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Abstract
• Ultrastructural examination of the stroma of simple nasal polyps has shown that there is an edematous framework of fibroblasts with abundant interdigitating cytoplasmic processes, a plexus of inflamed blood vessels, and a mixed infiltrate of active inflammatory cells. Solitary cilia were seen to arise from the stromal mesenchymal cells; no mycoplasma or viral inclusions were present. These features may have a relationship to the pathogenesis of nasal polyps. An immunologically induced liberation of vasoactive amines from mast cells results in increased capillary permeability and a consequent excess of intercellular fluid; the stromal cells attempt to check this expansion by an increase in collagen synthesis. (Arch Otolaryngol 102:589-595, 1976)